Pharmacy to Dose: The Critical Care Podcast · Nick Peters

April 2024 Literature Review Series

·1 hr 19 min·5 clips

Discover how Chiesi supports clinical pharmacists in critical care with forward-looking initiatives.

This episode is a monthly literature review focused on critical care research published in April 2024. Host Nick Peters is joined by former PGY-2 critical care pharmacy residents Katherine Kessel and Ming-Mei Zhang. They analyze recent peer-reviewed publications to identify findings that could influence clinical practice. The group examines a study on the use of balanced crystalloids versus normal saline in patients with traumatic brain injury. They discuss the CRISTAL trial, which investigated crystalloid use in intensive care units. Another reviewed article explores the management of atrial fibrillation in patients who are critically ill. The conversation covers research on adjunctive corticosteroids for community-acquired pneumonia. A study on thromboprophylaxis dosing in obese patients is also analyzed. The hosts review literature concerning the reversal of direct oral anticoagulants. They evaluate new data on the treatment of *Clostridioides difficile* infections. An interesting insight is that the CRISTAL trial's findings might not be directly generalizable to the specific neurotrauma population. The discussion reveals nuanced considerations for anticoagulant reversal strategies in emergency settings. The analysis of the corticosteroid study highlights ongoing debate about patient selection and mortality benefits. The hosts point out practical challenges in applying weight-based thromboprophylaxis protocols. They emphasize the importance of distinguishing between different direct oral anticoagulant agents. The conversation on *C. difficile* touches on evolving fidaxomicin dosing strategies. The tone is educational and conversational, with hosts speaking as practicing clinical pharmacists. The style is a structured journal club discussion aimed at translating research into clinical takeaways. Critical care pharmacists and pharmacy residents seeking to stay updated on recent evidence would find this episode valuable. Listeners looking for a broad medical overview or narrative storytelling might prefer a different format.

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