The Skeptics' Guide to the Universe is a long-running, weekly panel-format podcast (over 900 episodes) hosted by neurologist Steven Novella. Each episode brings together a consistent group of co-hosts — Bob Novella, Jay Novella, Evan Bernstein, and Cara Santa Maria, with occasional appearances from Shane Novella — who take turns presenting science news items they have each researched. The format is conversational, with hosts building on and sometimes correcting one another's interpretation of a study or claim rather than following a scripted structure. Segments span space exploration and NASA program updates including the Artemis lunar missions, physics and astronomy news such as antimatter transport and dark matter evidence, biology and genetics topics like CRISPR-edited crops and AI-designed bacteriophages, energy technology such as fusion power developments from companies like Helion Energy, and cognitive science topics like confirmation bias and motivated reasoning. A recurring throughline is applying skeptical methodology to specific claims in the news, ranging from outright pseudoscience, such as a ground-penetrating-radar 'Noah's Ark' story, to medical misinformation around vaccine hesitancy. The show periodically turns its skeptical lens on the practice of science itself, discussing the replication crisis, statistical malpractice such as p-hacking, and the difference between relative and absolute risk in reported studies. Guests appear occasionally, generally researchers discussing their own published work, but the panel of regular hosts carries most episodes. The show suits listeners who already have an interest in science literacy and critical thinking and want a weekly roundup of science news filtered through a skeptical framework, rather than a single-topic interview show. Production is a straightforward audio panel discussion without narrative framing, and the hosts reference past episodes and running jokes that reward regular listening.